Posts by Super User

Derivation/Development:  There are NK/T cell progenitors in bone marrow. There is a common T/NK progenitor cell. If this progenitor migrates to thymus, majority will rearrangement and become T cells. However,…

Neutrophils comprises in humans 50-70% of all circulating leukocytes, whereas in mice they represent 10-25 of circulating leukocytes. (Rosales "Neutrophils at the crossroads of innate and adaptive immunity". J. Leukoc…

Granulocytes are innate immune cells that contain specialized granules to provide the first line of immune defense. Upon arrival at the site of infection, they participate in the inflammatory reaction…

 Many diseases are characterized by pathogenic autoantibodies such as hemolytic anemia (erythroctye surface antigen), graves' disease (thyroid stimulating hormone R). There are several ways to deal with autoreactive immature B…

Thymus-dependent (TD) activation: B cell activation can occur one of two ways. The first way depends upon TH cells and is called Thymus-dependent (TD). The other way does not and is referred to…

See also antibody diversity B-cell development begins as lymphoid stem cells differentiate into progenitor B cells (pro-B cells) which express a transmembrane tyrosine phasphatase called CD45R. Proliferation and differentiation of these pro-B…

One of the critical factors underlysing the difficulty in generating human Mabs is the low frequency of antigen specific B cells in the peripheral blood. Typically, antigen specific B cells…

See also antibody production methods B cell activation can occur one of two ways. The first way depends upon TH cells and is called Thymus-dependent (TD). The other way does not and is…

Proliferation Lymphoproliferative assay (LPA): largely measures the in vitro proliferative capacity of CD4T cells. Typically PBMC are placed in culture with recombinant protein antigens for 5-7 days and then pulsed with…