generation of T regs
T regs similar to Th1 and Th2 cells, arise from naive precursors and can be differentiated in vitro. Effects of Cytokines In the case of murine , it has been shown…
regulatory T cells
It is now widely accepted that several types of regulatory cells exist, some of which are induced in response to infectious challenge and some that are considered natural regulators. Regulatory…
Memory T cells
In contrast to naive T cells, Memory/effector cells migrate mostly through peripheral tissues. This migration mediates rapid protective responses and is controlled by the expression of different sets of integrins…
CD4+ T helper cells
Types of T helper cells T helper cells (CD4+ T helper cells) can be divided into two major subsets termed , based on their pattern of secreted cytokines. T cells expressing cytokine…
T cells
Most T cells express the alphabeta TCR (T cell receptor) protein and have a helper (CD4+) or cytotoxic (CD8+) phenotype. A subset of cytotoxic T cell also express NK associated…
lymphocytes
Lymphoctyes are one of many types of white blood cells produced in the bone marrow during hematopoiesis (The other white blood cells or "leukocytes" being neutrophils, monocytes, eosinophils and basophils).…
DC surface markers
The molecules expressed by human DCs can be divided into receptors for antigen uptake, such as TLRs, RcR, CD46, CD150 and C-type lectins, such as DC-specific ICAM-3-grabbing nonintegrin (DC-SIGN) migration…
plasmacytoid DCs
2 main DC subsets include pDC (CD11c+B220+) and myeloid DC (CD11c+CD11b+). Markers: Mouse pDCs CD45R (B220), CD8a Human pDCs express CD45RA CD11c-CD123+ plasmacytoid DCs (PDCs) are though to share precursor…
Role of DCs in tolerance
Two general mechanisms have been proposed by which DCs might maintain peripheral tolerance. The first is that a subtype of specialized regulatory DCs is involved. The second is that all…