Stability assays
There are various methods available for assessing the stability of protein formulations, incluidng antibody formulations, based on the physical and chemical structures of the proteins as well as on their…
Water soluble synthetic polymers (PEG)
Water Soluble Synthetic Polymers PEG Introduction: Water soluble synthetic polymers have been used for protein stabilizing agents.s Poly-(ethylene glycol) (PEG) is one such polyer that has been extensively studies both…
Immunoglobulin stabilization
See aslo antibody variants in Antibody purification Unpredictability in Antibody Formulations/stabilization mAbs generally have reasonable stability, and about half of all mAb drug products are in liquid dosage form. Goswami (Antibodies 2031,…
Protein Stabilization
Companies working on protein stabilization: Ambient See also Immunoglobulin stabilization and Buffer conditions Importance and Difficulty of Drug Delivery and Formulation The success of most peptide and protein drugs is dependent…
Pharmacogenomics
Pharmacogenomics refers to the entire spectrum of genes that determine drug behavior and sensitivity. It assesses the genetic basis of drug response and toxicity in target patient populations. Pharmacogenetics focuses on drug response as…
Pharmacology
X-refs: Remington's Pharmaceutical Sciences, 18th Edition (A.R. Genrmo, ed.), 1990, Mack Publishing Company Pharmacology is a branch of science which deals with with characteristics or properties of a drug, especially those…
Types of nanoparticles
Gene delivery is, arguably, the biggest bottleneck in gene therapy. Adeno-associated virus (AAVs) are the historical mainstay, but they are expensive to manufacture and have payload limits and immunological issues.…
Magnetic nanoparticles
See also antibodies as drug targetting agents Introduction: Magnetic nanoscale particles are of particular interest with respect to nanoparticles due to their magnetic properties. These nanoparticles ave been used to…
Nanoparticles
Companies: Bind therapeutics (developing "accurins" which polymeric nanoparticles which target and accumulate at disease sites). Continuity Biosciences. (The Continuity Biosciences technology portfolio ranges from nanofluidic systems for drug delivery to cell storage…
Immunoadhesins
immunoadhesin combines the framework sequences from a human mAb with sequences from a human protein that carries a target-recognition function. The most common example of this type of fusion protein combines the…