Topoisomerases
DNA topoisomerases are able to modify the termtiary structure of circular DNA. Prokaryotic enzymes do not require ATP, as do eukaryotic topoisomerases. DNA topoisomerases have been classified into two types:…
Polymerases
Polymerases are enzymes which polymerize new DNA or RNA using an existing DNA or RNA template. Polymerases are essential in DNA replication and transcription. PARPS See outline Tankyrasses (TANKs) TANKs…
Oxidoreductases
An oxidoreductase is an enzyme that catalyzes the transfer of electrons from one molecule called "the reductant" or "electron donor" to another molecule called "the oxidant" or the "electron acceptor". This group…
Neuraminidases
Neuraminidases (also known as sialidases): are enzymes that have been identified in many viruses, bacteria and eukaryotes that cleave sialic acid moieties and can be involved in many functions in vivo. It has…
Glycosidase
See also ABO blood antigens See also removing A and B antigens from Type A, B, and AB cells Glycosidase refers to an enzyme that cleaves a covalent bond between sequential sugars in…
Glycosyltransferases
The glycosyltransferases are a family of some 250-300 different intracellular, mebrane-bound enzymes that participate in the coordinate biosynthesis of the glycostructures of polypeptides, including glycoproteins, proteoglycans and glycolipids. They are…
Serine proteases
Serine proteases are a large family of proteoytic enzymes that include digestive enzymes, trypsin and chymotrpsin, components of the complement cascade and of the blood clotting cascade, and enzymes that…
Proteases
Mechanisms Proteases (also termed "proteolytic enzymes" "peptidases" or "proteinase") attack their substrates using 2 approaches. Exopeptidases remove single residues or dipeptides sequentially from either the N-terminus or C-terminus depending on…
CRISP/Cas9
Introduction to CRISPR/Cas9 Companies: Intellia Aldevron (Danaher) Non-profits: Innovative Genomic Institute Innovative Genomics Insttitute Education Section Biopku CRISPR (clustered regularly interspaced short palindromic repeats)-Cas (CRISPR assocaited) systems are prokaryotic adaptive immune systems…
CRISP
Companies: Beam Therapeuticsm Caribou Biociences, CRISPR Therapeutics, Editas Medicine, Intellia Therapeutics, Poseida, Prime Medicine, Sangamo Therapeutics, Wave LifeSciences, Verve Therapeutics Introduction: CRISPR Cas systems are a main protective mechanism of…