IgA
companies: Secretory IgA IgA synthesis exceeds the combined total of all the other immunoglobulin classes. Where IgA is found, Generally IgA may be monomeric (i.e., a single molecule), dimeric (composed of two…
Cytokines
For a nice list of monoclonal antibodies currently on the market see (Shukla, "Recent advances in large-scale production of monoclonal antibodies and related proteins" Trends in Biotechnology, 28(5) pp. 253-261)…
complement components
Antibodies to Complement Pathway Components Preclinical studies using animal models and human derived samples demonstrate that inhibition of complement ameliorates many inflammatory and autoimmune disease manifestations. The AP pathway has…
specific disorders
For therapeutic applications of IL-6 antibodies see IL-6 under "immunology" For cancer specific antibodies see the "cancer" section Cancer and Lymphomas: The first antibody for the treatment of cancer was a chimerica…
bi-specific antibody production & isolation
As to Bispecific antibodies generally see Bispecific antibodies under structure and types As to Be-specific antibody purificaiton see bi-specific antibodies under particular types of antibodies purified see also Engineering of…
polyclonal antibody production
To constrain costs, strategies have been developed to produce recombinant polyclonal antibodies in a single pot. This process by passes the manufacturing hurdles assocaited with individual antibody production but introduces…
monoclonal antibody production
See also Immunization and ways to increase immunogenicity See also B cell activation . See also cell culture in Biotechnology Introduction Since the development of the hybridoma technology by Kohler and Milstein 35…
prokaryotic systems
For the purification of antibodies from inclusion bodies, see Protein Purification and Antibody Purification. Antibody fragments were usually manufactured in mammalian cells, but alternative production systems such as E. coli, Pichia yeasts…
eukaryotic systems
Mammalian Cells: About 60-70% of all recombinant protein pharmaceuticals and 95% of approved antibodies are still produced in mammalian cell lines despite relatively high produciton costs and diffiulty in handling.…
Recombinant gene expression
The development of most manufacturing processes for recombinant proteins such as antibodies in mammalian cells usually follows a a sehme of recombinant gene with the necessary transcriptional regulatory elements being…