DNA rearrangement
See also B cell Development The ability of the immune system to recognize antigens depends on antibodies generated by B cells and on antigen receptors expressed by T cells. These…
Binding affinity
HyPare (automatically claculates the impact of mutations on a per-resiude basis for all resiudes of a protein-protein interaction. An affinity pair is a pair of two molecules that mutually bind with…
Antibody diversity
IMGT genome database (classifies the immunoglobulin (IG) and T cell receptor (TR) genes from vertebrate species The amino terminal regions of H and L chains are characterized by extensive variability in…
Antibodies in Nature
Immunogetics Information Sytstem Isotypes Expressed Immunoglobulins are expressed in 2 forms: secreted antibody that is produced by plasma cells, and membrane bound antibody that associates with Ig-?/Ig-? heterodimers to form…
Production Techniques
Bispecific Antibodies (See bispecific antibody production under cell expression) The generation of bispecific IgG molecuels is difficult due to the fact that the antigne-bnding sites are built by the variable…
Engineered antibodies
See "homeostasis and half life" of antibodies See also FcyR structure See also fc receptors under signal transduction web database of mAbs with clinical indications supplies: Quickchange mutagenesis kit (Agilent Technologies)…
Common Analytical Techniques
Differential scanning calorimetry (DSC) can be used to examine the stability of the tertiary structure of antibody preparations. (Brass, Pharm Acta Helv. 1996, 71(6): 395-403) Immunoassay (ELISA): can be used to…
Waste Water Treatment
Septic Systems Many rural and suburban areas rely on septic tanks which are containers into which sewage flows. The solid material settles and is subject to microbial decomposition. The liquid…
continuous chromatography
See also simulated moving bed chromatography (this is a form of continuous chromatography) under moving bed. Definitions: Binding capacity and mass transfer: The binding capacity strongly depends on the affinity…
Peptides and Mimotopes
Companies: Abreos Biosciences Links of interest: Mimo DB Definitions Anti-Idiotype antibody: binds to the idiotype of another antibody, usually an antibody drug. Idiotype: is the sepcific combination of idiotopes present…