virology

Particular Type of Antigen-Fusion Polypeptides Thermally Responsive Polymers Fused to Antigens --Antigen-Carrier-Elastin-Like Peptide Fusion Peptides: Krebs (US13/990344) discloses fusion proteins of an immunogenic carrier protein containg a thermally-responsive aggregation (TRA) polypeptide…

See also antibody production  Immunogen dosage and route of administration also affect immune response. A dose may be too small or too large to induce an immune response. An insufficient dose…

Introduction: Adjuvants are substances which when mixed with an antigen enhance the immunogenicity of that antigen are often used to boost the immune response. Some adjuvants prolong the persistence of antigen in…

Proteins function as the most potent immunogens, with polysaccharides ranking second. In contrast, lipids and nucleic acids generally do not serve as immunogens unless they are complexed to proteins or…

The 3 dimensional structure of a compound can influence immunogenicity. Peptides used in a particular vaccine immunogen are often chosen such that they generate an antibody response to the location…

Adjuvants (see outline) ProPred (graphical web tool for predicting MHC class I binding regions in antigenic protein sequences).  Deisgn for binding to MHC Molecules: It is well established that binding…

Factors which Determine Immunogenicity Immunogenicity is the ability to induce a humoral and/or cell mediated immune response. Although a substance that induces a specific immune response is usually called an "antigen" the more…

Companies: Osivax Nucleic acid based immunization exhibits a number of advantages. For example, the manufacture of nucleic acid based vaccines is straight forward, relatively inexpensive. DNA Vaccines Potential advantages: DNA based…

See "ways to increase immunogenicity" on outline See WHO   See History of Vaccines  Active immunization refers to stimulation of an immune response by challenge with an immunogen. Active immunization occurs…

helpful websites:  NIH Vaccines    Immunisation   Immunisation Guidelines for Ireland 2008 Edition, Royal College of Physicians of Ireland (good summary of all of the vaccine schedules) GAVI: the vaccine alliance   International Society of Travel…