Acne vulgaris: afficts more than 50 million pople in the US. P. acnes, a gram-positive bacterium, is strongly associated with acne vulgaris. The inflammatory stage of acne vulgaris is the greatest concern to patients, as the lesions produced may lead to scarring.

1. Treatment: Systemic therapies for acne target P. acnes using antibiotics or target the follicle with retinoids such as isotretinoin.

a. Systemic antibotic treatments have limitations in that they may kill skin bacterial non-specifically impacting the homeostasis of resident dermal microflora. Oral antibiotics also contain the risk of harming intestinal microflora.

b. Istretinoin, 13-cis-retinoic acid, is a vitamin A-derived retinoid that has been widely prescribed for systemic treatment of severe acne. Although it was first approved in the US in 1982 for treating severe acne, it suse has become tighly regulated.

c. Sialidase inhibitors: Adherence of P. acnes to human sebocytes has been shown to be augmented after removal of sialic acids form the cell surface and that acne progression and recurrence can be effectively prevented by antibodies against sialidase of P. acnes.

Acne Scares: 

CO2-Skin Resurfacing:

Sublative™ fractionated bi-polar radio frequency technology places the heat energy effectively into the upper dermis where it can produce a significant increase in both collagen and elastin with minimal epidermal disruption.syneron-and Candela