ARDS
ARDS is a severe, often life-threatening of several systemic disorders and direct injury to the lungs. It is major component of multiple organ dysfunction syndrome (MODS) and a manifestation of the systemic…
Pulmonary fibrotic disorders
See also lysyl oxidase-type enzymes in the "enzyme" section Classification: Pulmonary fibrotic disorders are classified into the following groups, in order of their relative occurrence: idiopathic pulmonary fibrosis (IPF), nonspecific interstitial…
Airway Disorders
Airway diseases include diseases which effect the respiratory tract (e.g., lungs, mouth, nose, pulmonary, alveoli, pharynx, larynx, trachca, and bronchi). Airway diseases, such as asthma and COPD are a major…
SLE
SLE or "lupus" is used to describe a chronic potentially debilitating or fatal autoimmune disease in which the immune system attacks the body's cells and tissue. SLE is a prototype…
Lupus
See also: Drug targetting under "Pharmacology" Introduction: Lupus Nepthritis also known as "membranous glomerulonephritis" refers to an inflammation of the kidney caused by the chronic autoimmune disease SLE. Those afflicted with…
Autoimmune Diseases
See also "Hemolytic anemia" under "blood diseases" and "Hemolytic uremic syndrome" under "Kidney diseases". Autoimmune diseases are generally understood to be diseaes where the target of the disease is "self"…
PI-3 Kinases
See also MAP Kinases Classes and Structure: The PI3Ks are an ancient family of intracellular kinases that evolved to mediate nutrient sensing and metabolic control. In mammals, there are 8…
PKC
PKC activity has been coupled with the preservation of cell survival. The catechin EGCG has been reported to protect neuronal cell lines against cell death induced by 24 h exposure…
Inhibitors of NF-kB
Given the important role that NF-kB plays in the regulation of a large number of proinflammatory genes, there is a growing interest in targeting it in order to affect the…
Activation of NF-kB
All known have been shown to signal through Toll/IL-1R homology (TIR) domain-containing adaptor molecules, MyD88, and/or TIR domain-containing adaptor-inducing IFN-? (TRIF). Mice deficient in both MyD88 and TRIF are unresponsive to…