microparticles

May 13, 2023Posted indrug delivery
Companies:  Elektrofi (developed Hpercon which are protein microparticles. Gentle dehydration results in smooth, spherical microparticles that dissolve into fully functional protein monomers in the subcutaenous space. They take drug substances…

Brain Drug Delivery

April 27, 2023Posted indrug delivery
Diseases of the CNS remain the world's leading cause of disabilities, accounting for more hospitalization and prolonged care than almost all other diseases combined. Scuh CNS diseases include brain tumours,…

BispAb Formats

April 9, 2023Posted inPatent Law Cases
A main discrimination of recombinant bispecific antibodies is format and in particular the presence or absecne of an Fc region. Bispecific antibodies (biSpAbs) with no Fc will lack Fc mediated…

Conjugation & Linkers

April 2, 2023Posted indrug delivery
Antibody-Drug Conjugates (ADCs) are designed to bind to cell surface receptors and get internalized thorugh receptor medaited endocytosis, then trafficked into endosomes and ultimately lysosomes. Following internalization, ADC antigen complexes…

RNA Interference

January 8, 2023Posted inBiotechnology
Introduction: RNA interference (RNAi) is an endogenous cellular process in which double-stranded small interfering RNA molecules (siRNAs) bind to a specific mRNA target and trigger its degradation, resulting in reduced…