Bioinformatics

Free software: AlphaFold (structural protein database; predicts a proteins 3D structure from its amino acid sequence) Openfold3 (collaboration with Nvidia) Latent-X (by Latent Lab is a de novo protein design…

General Search links:  Information hyperlinked over proteins (iHOP) (this is a useful database to find information regarding proteins as well as synonyms for the proteins) Database entry portals:  SRS SRS DBGET NCBI Cross-Ref DB (one of…

Several goals for cancer genomics and proteomics are (1) a better understanding of cancer development, (2) providing a molecular basis for histological diagnoses, and (3) subdividing tumor types according to…

Phosphorylation is one of the most frequently occurring postranslational modifications (almost 30% of all proteins are thought to be phosphorylated). In Eukaryotes, regulation of cellular processes is achieved through reversible…

X-Refs:National Human Genome Research Institute (comparison of genomes of other species with our species to determine protein function) See also Protein-Protein Interaction assays under biotechnology. The Daunting Task of predicting Protein…

AlphaFold (put in amino acid sequence and obtain predicted 3D structure) More than 540,000 protein sequences have been deposited in the nonredundant database maintained by the National Center for Biotechnology…

Useful Links:  Human Proteome Map Portal contains translation of protein products derived from over 17k human genes.   Proteomic Data Base   world-wide Protein Data Bank (contains more than 126,000 experimentally determiend atomic level 3D structures…

See also Lectin Affinity chromatography under Affinity Purification  Definitions Glycan: refers to the carbohydrate portion of a glycoconjugate, such as a glycopeptide, glycoprotein, glycolipid or proteoglycan. Regnier (US8,568,993)  Glycomics is the systematic…

See also CRISP gene editing under Enzymes and endonucleases Gene editing refers to the introduction of desired changes at specific genomic loci. The original strategy for gene editing was to use…

Once conserved non-coding sequences (CNSs) regions have been identified, the next step is to evaluate their function in biological experiments. There are various techniques to assess regulatory function. DNASE I…