Biotechnology

Companies: n-Lorem (charitable antisense therapy for rare diseases). Avidity Biosciences (acquired by Novartis) (Antibody Oligonucleotide Conjugates (AOC™) platform) Introduction: RNA interference (RNAi) is an endogenous cellular process in which double-stranded…

In molecular biology and genetics, a transcription factor (sometimes called a sequence-specific DNA-binding factor) is a protein that binds to specific DNA sequences, thereby controlling the flow (or transcription) of…

Companies: Tevard Biosciences (TRNA therapies) See Prokaryotics for differences with their translation Translation is the process of converting the nucleotide sequence of mRNA into a protein. This is accomplished in…

There is evidence that histone acetylation and deacetylation are mechanisms by which transcriptional regulation in a cell is achieved (Grunstein, M. (1997) Nature 389: 249-52). These effects are thought to…

For Histone methylation see outline. See also Regulation of Transcription. Epigenetics Epigenetics has two main elements; DNA methylation and histone modifications. Transcriptional activation of tissue-specific genes generally involves both DNA demethylation…

See also Chromosomes and DNA Methylation and deMethylation and role of Epigenetic Modifications in Driving Th1/Th2 Development and Fetal Assays based on Chomatin epitopes and Histone aceylation. A large number of covalent modifications of histones have been…

RNA Capping: In eukaryotes, transcription is only the first step leading up to a mature mRNA which can be transported out of the nucleus to the cytoplasm of the cell…

See also transcription Comparative genome analyses indicate that increases in gene number do not account for increases in morphological and behavioral complexity. For example, the nematode worm has about 20,000…

See also RNA capping and splicing Transcription in eukaryotic cells occurs in the nucleus followed by translation in the cytoplasm. Transcription is the transfer of information from a double stranded…