Gene Therapy
See also CRISP gene editing, RNA interference and Gene Delivery. Companies: Dark Horse Consulting Group Gene therapy encompasses the genetic modulation of cells and/or tissue in order to achieve a…
Viral Vectors
Adenoassociated viruses (AAVs): Companies: MeiraGTx (optimization of AAV vectors and promoter sequences. Riboswitch technology that is designed for control of gene expression by oral small molecules). 3PBIOVIAN Introduction: AAVs is…
Non-Viral Vectors
Non-viral vectors for gene delivery have attracted attention in the past decades becasue of their potential for limited immunogenicity, the ability to accomodate and deliver alrge size genetic materials and…
microparticles
Companies: Elektrofi (developed Hpercon which are protein microparticles. Gentle dehydration results in smooth, spherical microparticles that dissolve into fully functional protein monomers in the subcutaenous space. They take drug substances…
Brain Drug Delivery
Diseases of the CNS remain the world's leading cause of disabilities, accounting for more hospitalization and prolonged care than almost all other diseases combined. Scuh CNS diseases include brain tumours,…
Conjugation & Linkers
Antibody-Drug Conjugates (ADCs) are designed to bind to cell surface receptors and get internalized thorugh receptor medaited endocytosis, then trafficked into endosomes and ultimately lysosomes. Following internalization, ADC antigen complexes…
Buffer conditions
Besides pH, buffer components also play a role in stabilizing mAbs. Sodium phosphate and histidine are the most commonly used buffer components in commerical formulations. While sodium phosphate is more…
Stability assays
There are various methods available for assessing the stability of protein formulations, incluidng antibody formulations, based on the physical and chemical structures of the proteins as well as on their…
Water soluble synthetic polymers (PEG)
Water Soluble Synthetic Polymers PEG Introduction: Water soluble synthetic polymers have been used for protein stabilizing agents.s Poly-(ethylene glycol) (PEG) is one such polyer that has been extensively studies both…
Immunoglobulin stabilization
See aslo antibody variants in Antibody purification Unpredictability in Antibody Formulations/stabilization mAbs generally have reasonable stability, and about half of all mAb drug products are in liquid dosage form. Goswami (Antibodies 2031,…