drug delivery

Companies working on protein stabilization: Ambient See also Immunoglobulin stabilization and Buffer conditions Importance and Difficulty of Drug Delivery and Formulation The success of most peptide and protein drugs is dependent…

Pharmacogenomics refers to the entire spectrum of genes that determine drug behavior and sensitivity. It assesses the genetic basis of drug response and toxicity in target patient populations. Pharmacogenetics focuses on drug response as…

X-refs: Remington's Pharmaceutical Sciences, 18th Edition (A.R. Genrmo, ed.), 1990, Mack Publishing Company Pharmacology is a branch of science which deals with with characteristics or properties of a drug, especially those…

Gene delivery is, arguably, the biggest bottleneck in gene therapy. Adeno-associated virus (AAVs) are the historical mainstay, but they are expensive to manufacture and have payload limits and immunological issues.…

See also antibodies as drug targetting agents  Introduction: Magnetic nanoscale particles are of particular interest with respect to nanoparticles due to their magnetic properties. These nanoparticles ave been used to…

Companies: Bind therapeutics  (developing "accurins" which polymeric nanoparticles which target and accumulate at disease sites).  Continuity Biosciences. (The Continuity Biosciences technology portfolio ranges from nanofluidic systems for drug delivery to cell storage…

immunoadhesin combines the framework sequences from a human mAb with sequences from a human protein that carries a target-recognition function. The most common example of this type of fusion protein combines the…

Head-to-head promoter expression vector: refers to a promoter pair being placed in close proxmity so that transcription of two gene framgents driven by the promoters occurs in opposite directions. (WO2004/061104) provides…

FDA cellular & gene therapy guidance Gene therapy involves the transfer and expression of a therapeutic gene. The nucleic acid transfer needs to have a dominant effect on the cell's phenotype.…

Gelatin: is a collection of high molecular weight peptides produced by hydrolysis of collagen usually isolted from bovine or porcine skin. Gelatin is obtained by the partial hydrolysis of collagen dervied…