RNA Vaccines
Introduction: Two different strategies have been pursued for immunotherapy with in vitro transcribed RNA (IVT-RNA), which have both been successfully tested in various animal models. Either the RNA is directly…
Dendritic Cell Vaccines
Definitions: Antigen Sensitized Dendritic Cells: are DCs which have been contacted with an antigen(s) for which an increased immune response is desired. For example, an immature DC (see below) may…
Dendritic Cell Development
See also Drugs/agents which inhibit DC maturation Introduction/Definitions: DC are derived form bone-marrow progenitors (CD34+) and are present at two stages in the body. DC differentiation involves the change from…
Applications of Complement Regulators
See also specific diseases for references to CRegs and Drug Targetting under Pharmacology CRegs for the Treatment of Diseases CR1: Levin (US 6,169,068) teaches a method for treating diseases involving complment by…
Complement Pathways
There are 3 distinct pathways of complement activation. The classical system is antibody dependent whereas the other 2 pathways, lectin and alternative, are antibody independent and are initiated by reaction…
Complement receptors
See also Regulation of the Complement system . See also the use of complement receptors for drug targeting (under "pharmacology" and "drug delivery"). There are three known gene superfamilies of complemen…
Functions of the complement system
Complement has a variety of important functions which includes: (1) opsonization of antigens: including bacteria by phagocytosis. The complement component, C3b is the major opsonin of the complement system. Phagocytic cells, as…
Functions of the complement system
Complement has a variety of important functions which includes: (1) opsonization of antigens: including bacteria by phagocytosis. The complement component, C3b is the major opsonin of the complement system. Phagocytic cells, as…
Graft-versus-host-disease (GVHD)
Introduction/Definitions: Autograph: transplanted tissue from one site on a donor and the recipient. Typical examples are skin replacement in burn repair and the use of a vein to fashion a…
Liver transplantation
Partial Liver Transplantation Massive hepatic resection is the only option for some patients with primary or secondary liver tumors. With regard to small-for-size (SFS) liver transplantation, the use of partial…