immunology

Definitions: Antigen Sensitized Dendritic Cells: are DCs which have been contacted with an antigen(s) for. which an increased immune response is desired. For example, an immature DC (see below) may…

See also Drugs/agents which inhibit DC maturation DC are derived form bone-marrow progenitors (CD34+) and are present at two stages in the body. DC differentiation involves the change from multipotential…

See also specific diseases for references to CRegs  and Drug Targetting under Pharmacology CRegs for the Treatment of Diseases CR1: Levin (US 6,169,068) teaches a method for treating diseases involving complment by…

There are 3 distinct pathways of complement activation. The classical system is antibody dependent whereas the other 2 pathways, lectin and alternative, are antibody independent and are initiated by reaction…

See also Regulation of the Complement system . See also the use of complement receptors for drug targeting (under "pharmacology" and "drug delivery"). There are three known gene superfamilies of complemen…

Complement has a variety of important functions which includes: (1) opsonization of antigens: including bacteria by phagocytosis. The complement component, C3b is the major opsonin of the complement system. Phagocytic cells, as…

Complement has a variety of important functions which includes: (1) opsonization of antigens: including bacteria by phagocytosis. The complement component, C3b is the major opsonin of the complement system. Phagocytic cells, as…

Graft-versus-host-disease (GVHD): GVHD (graft-versus-host-disease) occurs when donor derived T cells recognize and react to histo-incompatible recipient antigens leading to a variety of host tissue injuries. GVHD is the major cause of morbidity…

Partial Liver Transplantation Massive hepatic resection is the only option for some patients with primary or secondary liver tumors. With regard to small-for-size (SFS) liver transplantation, the use of partial…

United Network for Organ Sharing See also Kidney Diseases  See also MHC In 1901, Landseiner discovered ABO blood group antigens. In 1954, Murray performed the first successful kidney transplant between…