lymphocytes
Lymphoctyes are one of many types of white blood cells produced in the bone marrow during hematopoiesis (The other white blood cells or "leukocytes" being neutrophils, monocytes, eosinophils and basophils).…
DC surface markers
The molecules expressed by human DCs can be divided into receptors for antigen uptake, such as TLRs, RcR, CD46, CD150 and C-type lectins, such as DC-specific ICAM-3-grabbing nonintegrin (DC-SIGN) migration…
plasmacytoid DCs
Introduction/Difference Plasmacytoid DC with Myeloid DCs: The two major subsets of human DCs, myeloid and plasmacytoid DCs (mDCs and pDCs, respectively) both have antigenpresenting capacity although mDCs are generally considered…
Role of DCs in tolerance
Two general mechanisms have been proposed by which DCs might maintain peripheral tolerance. The first is that a subtype of specialized regulatory DCs is involved. The second is that all…
factors affecting DC development
Th1 and Th2 patters of cytokine secretion correspond to activated effector phenotypes generated during an immune response. They do not exist among naive T cells. When first stimulated by antigen…
DC development
There are two main DC subsets; (1) Myeloid (mDC) and (2) Myeloid DC and pDC different in Toll-like receptors able to sense activation signals from pathogens. Several other functional discrepancies have…
T cell priming by DCs
DCs have been identified as the most effective antigen presenting cells (APC). They have long dendritic processes and possess an exceptional capability to capture antigens (Ags), process and present antigenic…
maturation stimuli
n vitro, maturation/activation can be induced by a number of stimuli, including cytokines such as TNF-? and/or other cytokines, monocyte-conditioned medium, or CD40 receptor cross-linking. Immature DC comparable to those…
inhibition of DC maturation
Drugs which Inhibit DC Maturation and/or Function A diverse variety of pharmacologic agents have been shown to inhibit DC maturation and to promote their tolerogenicity. Acetylsalicylic acid (Aspirin;) Although asprin has…
DC subsets in mice
As many as six subsets of DCs have been described in mice including mDCs and pDCs which are also found in Both DC types are professional antigen presenting cells (APCs) but…