Depression
Introduction: Depression is neurological disorder with psychiatric symptoms. While it is often categorized as a mental health condition, research has shown that depression is linked to structural and functional changes…
Anziety
Selective Serotonin Reuptake Inhibitors: Lexapro (escitalopram): Lexapro (escitalopram) is an antidepressant from the group of drugs called selective serotonin reuptake inhibitors (SSRIs) and is used to treat certain types of…
Oxidized and Reduced Variants
See also Oxidation and Reduction in Biochemistry Disulfide Bond Variants Disulfide reduced variants have one more disulfide bonding cystein(s) chemically reduced to the free thiol form. This variant can be monitored…
Anion Mixed Mode (cation exchanger)
Anion exchange and hydrophilic interaction: Negatively charged mixed mode ligands below to the cation exchanger mixed mode (for example CaptoAdhere) (Melinda, US 20170058019) Examples include Capto-QTM which is a strong anion exchange and…
Altered Effector Function
The effector functions mediated by the antibody Fc region can be divided into (1) effector functions that operate after binding of antiobdy to an antigen (these funcitons involved the participation…
BispAb Formats
A main discrimination of recombinant bispecific antibodies is format and in particular the presence or absecne of an Fc region. Bispecific antibodies (biSpAbs) with no Fc will lack Fc mediated…
Ultrasmall Superparamagnetic Iron Oxide Nanoparticles
SPIO refers to superparamagentic iron oxide particles. They are commonly made of maghemite (Fe2O3) or magnetite (Fe3O4) having crystal-containing regions of unpaired spins. Those magnetic domains are disordered in the…
Regulation of the complement system
See also Applications of Cregs: Complement Receptor 1 (CR1; CD35; C3b/C4b receptor): is present on erythrocytes, monocytes/macrophages, granulocytes, B cells, some T cells, splenic follicular dendritic cells and glomerular pdocytes. CR1…
Regulation of the complement system
See also complement inhibitor targetting under "Pharmacology" and "Drug delivery" See also Human Complement Regulatory Proteins (CRegs) See also disease mechanisms of viruses and bacteria for how pathogens use complement regulatory proteins to evade the…
Complement Assays
Various assays/methods can be used to mesasure activities of complement pathway molecules and activaiton of the complement system. (see US Patent No. 6,087,120 and Newell, J Lab Cin Med, 100:437-44,…