Patent Law Cases

Various assays/methods can be used to mesasure activities of complement pathway molecules and activaiton of the complement system. (see US Patent No. 6,087,120 and Newell, J Lab Cin Med, 100:437-44,…

C3a and C5a (below) are anaphylatoxins which can trigger mast cell degranulation, which releases histamine and other mediators of inflammation, resulting in smooth muscle contraction, increased vascular permeability, leukocyte activaiton,…

Overview The Lectin pathway is initiated by mannan-binding lectin (MBL) which is a protein that binds specifically to mannose residues in bacterial cell walls. It is a phylogenetically ancient mechanism which was first shown…

See also Fc receptors under signal transduction The classical pathway is is a major effector of the humoral branch of the human immune response. the CP is typically triggered by…

Overview The AP is responsible for 80-95% of total complement activity. The AP is a complement activation pathway which is triggered by artificial surfaces such as LPS from Gram negative…

See also therapeutic antibodies against specific complement components in the "antibodies" section.  See also CR2 targetting of complement inhibitors for treatment of disease under "pharmacology"   See also specific diseases throughout ypatent for the role which complement plays in these…

The complement system consists of about 31 proteins, acting within a cascade-like reaction sequence, serving as control proteins or as cellular receptors. Some of the proteins are enzymes (C1r, C1s,…

A species identified as a mAb monomer with an additional light chain covalently associated through a disulfide bond formed between a L chain cystein and an engineered cystein in either…

Companies:  ALV.  Brookhaven Instruments   Malvern. Wyatt   Light scattering is one of the few absolute methods available for the determination of molecular mass and structure and is applicable over a broader…