Cytokines produced by DCs

DCs are known to produce the following cytokines:

DCs are efficient producers of IL12 that acts in inducing Th1 responses upon antigen presentation by these APC. 

LPS maturation dependent upregulation has been reported to occur with this cytokine (Chen, 2001).

IL-1?: LPS maturation dependent upregulation has been reported to occur with this cytokine.

IL-1?: LPS maturation dependent upregulation has been reported to occur with this cytokine.

IL-6: LPS maturation dependent upregulation has been reported to occur with this cytokine.

IGF-1: LPS maturation dependent downregulation has been reported to occur with this cytokine.

Chemokines produced by DCs

RANTES: LPS maturation dependent upregulation has been reported to occur with this chemokine.

MIP2: LPS maturation dependent upregulation has been reported to occur with this chemokine.

GROa: LPS maturation dependent upregulation has been reported to occur with this chemokine.

Chemokines upregulated upon DC maturation: Maturing DC are an abundant source of chemokines which are produced in a precise time-ordered fashion. Following stimulation with LPS, DC have an initial burst of MIP-1?, MIP-1? and IL-8 production, which ceases within a few hours. RANTES and MCP-1 are also induced, but in a more steady fasion. The amount of inflammatory chemokines released at these early time points by maturing DC is extremely high. 

At later time points DC produce mainly lymphoid chemokines. ELC is induced after 10-20 h, and TARC, MDC and PARC which are constitutively transcribed at low levels, are strongly upregulated with a similarly slow kinetics. 

CCR2: LPS maturation dependent downregulation has been reported to occur with this cytokine.

CCR5: LPS maturation dependent downregulation has been reported to occur with this cytokine.

CCR7: LPS maturation dependent downregulation has been reported to occur with this cytokine.