Hydroxyapatite (HA) See “hydroxyapatite”

Hydrophobic charge induction chromatography (HCIC): See “affinity chromatography”. 

Anion exchange and hydrophilic interaction: (see Anion Mixed Mode)

Anion and hydrophobic: (see Anion Mixed Mode)

Cation with hydrophobic interaction: See Cation mixed mode   

Cation, anion, and hydrophobic interaction: See Cation mixed mode  

Commercial examples include ABx. Ma (US14208043)

Cation exchange and hydrophilic interaction: See Cation mixed mode  

Commercial examples include Capto-MMC. Ma (US14208043)

Cation exchange + hydrophobic interaction + hydrogen bonding and pi-pi bonding: See Cation mixed mode 

Commercial examples include Capto-MMC. Ma (US14208043)

Affinity Chromatography + Charged species (e.g., Anion or Cation)

Affinity + AEX Groups:

Bian (US2007/0207500) disclsoes a method of coupling an affinity ligandsuch as Protein A or protein G to a support with an associative group that interacts with the solid support. The associative group can be a positive or a negative charge. Bian exemplfies reacting Sepharose 4B agarose beads with positively charged assocaitive groups (quaternary amine ligands).

Engstrand (WO 2006/043895) discloses separaing antibodies using a multi-modal serpation matrix to adsorbe undersired compounds while the antibodies remain free in the liguid where the multi-modal matrix includes first groups such as N,N-dimethylbezylamine which are capable of itneracting with negatively charged sites on the target compounds and second groups such as Protein A (Sepharose 6 FF) which are capable of at least one interaction other than charge-charge interaction with the target compound. 

Affinity + CEX Groups:

Minakuchi (US 15/022890, published as US 2016/0237113; see aslo US 14/424,718, published as US 9,890,191) discloses a method for purifying a target substance such as an immunogloublin using one integrated column with two different carries, a first carreir having an affinity ligand such as Protein A which has affinity for the immunoglobulin and a second column having a cation exchange group where the column is an integrated column having a first column having the 1st carrier or a second column having the 2nd carrier or is a single column having a mixture of the first and second carrier, and passing an eluate through the column to elute the target substance/antibody. 

Nakamura (JP2010133734) discloses a carboxylation carrier for affinity chromatography having a carboxylic acid group containing a thiol group and a ligand containing a primary amino group fixed to the carboxylation carrier by an amide bond. The carboxylated carrier is produced by first introducing an eopoxy group into a carrier for chromatography such as by using epichlorohydrin, reacting the epoxy group with a compound having a thiol group and a carboxylic acid group. Any material capable of introducing an epoxy group can be used such as a natural polymer carrier, a synthetic polymer carrier or an inorganic carrier. A ligand such as Protein A containing a primary amino group is immobilized on the carobxylated carrier by an amide bond using a dehydrating condensation agent.