DC subsets in mice
As many as six subsets of DCs have been described in mice including mDCs and pDCs which are also found in Both DC types are professional antigen presenting cells (APCs) but…
DC subsets in humans
Introduction: Human DCs comprise at least four types defined under cytokine-driven conditions in vitro. These include conventional or "myeloid" DCs: (1) CD14+ blood monocyte-derived DCs (moDCs); 2) dermal DCs or…
cytokines & chemokines produced
Cytokines produced by DCs DCs are known to produce the following cytokines: DCs are efficient producers of IL12 that acts in inducing Th1 responses upon antigen presentation by these APC. …
dendritic cells
Videos: Genentech (showing phagocytic cells taking in antigens) Introduction: The dendritic cell is one of the major means by which innate and adaptive immune systems communicate. It is believed that…
monocytes
See also Macrophages and T cell priming by DCs Introduction: Cells of the monocytic lineage play an essential role in initiating and maintaining immune responses by acting as antigen-presenting cells.…
white blood cells/leukocytes
Classes of Leukocytes White blood cells or "leukocytes" combat infection and in some cases phagocytose and digest debris. White blood cells are traditionally grouped into three major categories based on…
Immune cells
Monocytes Monocytes, unlike granulocytes, are long lived and can differentiate to become tissue resident macrophages and dendritic cells. Cells of the monocytic lineage play an essential role in initiating and…
B cell receptor (BCR) signalling
See also T cell activaiton in immune cells Antigen recognition by B cells is mediated by the B cell receptor (BCR), a surface-bound immunoglobulin in complex with signaling componets CD79alpha…
Antigen fusions
Particular Type of Antigen-Fusion Polypeptides Thermally Responsive Polymers Fused to Antigens --Antigen-Carrier-Elastin-Like Peptide Fusion Peptides: Krebs (US13/990344) discloses fusion proteins of an immunogenic carrier protein containg a thermally-responsive aggregation (TRA) polypeptide…
Dose & route
See also antibody production Immunogen dosage and route of administration also affect immune response. A dose may be too small or too large to induce an immune response. An insufficient dose…