THC
Introduction: Both delta-8 and delta-9 cannabinoids have a chain of carbon atoms, but delta-8 has the double bond on the eighth carbon, whereas delta-9 has it on the ninth carbon. This…
Cannabinoid receptors
Companies working on Cannabinoids for treatment of Disease: GW Pharmaceuticals Gold Seal (San Francisco based cannabis brand that specializes in high end flower). Introduction: Two cannabinoid receptors have been identified…
G Protein coupled Receptors
See also G proteins Introduction: G protein-coupled receptors(GPCRs) comprise a large superfamily of receptors which are prevalent through-out the human body, comprising about 60% of known cellular receptor types. GPCRs…
Enzyme Linked Receptors
See also Signal Transduction Enzyme linked receptors, when activated, either function directly as enzymes or are directly associated with enzymes that they activate. They are formed by single pass transmembrane…
Receptor tyrosine kinases
Introduction: Receptor tyrosine kinases (RTKs) influence the cell cycle, cell mitration, cell metabolism and cell proliferation --virtually all aspects of the cell are affected by signaling through these receptors. Some…
Receptor regulation
(1) Sensitization/Up Regulation: is a process whereby a cell becomes more responsive to a given concentration of a compound. This can occur in the following ways:Increase in functionality: deals with increased…
FcRn
See also use of FcRn for antibody purification See also engineering antibodies to increase/decrease binding affinity for FcRn The MHC class I-related neonatal Fc receptor (FcRn) is also known as the Brambell…
Fc receptors
See also "antibodies" for discussion of affinity and "isotypes" of antibodies for a discussion of the various effector functions of antibody isotypes. See also antibody engineering and specifically engineering of the FcyRs…
Plasma membrane receptors
Receptors are expressed in all types of cell membranes. Cell surface receptors are typically transmembrane proteins because they bind signal molecules in the extracellular space and generate different intracellular signals…
Signaling through TLRs
from Nature, 430 (2004) Introduction Although different TLRs are activated by distinct agonists, their cytoplasmic domains share the ability to transduct PAMP-generated signals to the IkB kinase (IKK) and mitogen-activated…