signal transduction

Function of NF-kB Nuclear factor NF-?B encompasses an important family of  which plays a central role in immunological processes by inducing expression of a variety of genes involved in inflammatory responses.…

NFAT is a calcium-regulated transcription factor which consists of four family members. It plays a crucial role in the transcriptional regulation of several cytokine-encoding genes, including the genes for IL-2 and…

AP-1 is a well characterized transcription factor composed of many different combinations of homodimers and/or heterodimers of the Jun, Fos, ATRF (activating transcription factor), and MAF (musculoaponeurotic fibrosarcoma) protein families. AP-1 regulates the transcription of various…

AIRE or Autoimmune Regulator is a putative transcription factor expressed primarily in mTECs that is believed to regulate transcription of many peripheral self-antigens. Absence of AIRE in human patients results…

Pentraxins (Pentaxins) are an evolutionary conserved family of proteins characterized by a pentraxin protein domain. They are a class of pattern recognition receptors. Members of the Pentraxin Family 1. C-Reactive…

The present of GATA-3 mRNA in naive T cells and induction of T-bet mRNA after cell activation, even in the absence of Stat1-mediated signals, are consistent with the early transcription…

TGF-beta superfamily is a large family of multifunctional proteins that regulate a variety of cellular functions including cellular proliferation, migration, differentiation and apoptosis. Members of the transforming growth factor beta…

Introduction to Signal Transducer and Activator of Transcription (STATs): STATs are latent transcription factors residing in the cytoplasm that become activated by phosphorylation on a single tyrosine residue. This phosphorylation…

Introduction: Both delta-8 and delta-9 cannabinoids have a chain of carbon atoms, but delta-8 has the double bond on the eighth carbon, whereas delta-9 has it on the ninth carbon. This…

Companies working on Cannabinoids for treatment of Disease:   GW Pharmaceuticals  Gold Seal (San Francisco based cannabis brand that specializes in high end flower). Introduction: Two cannabinoid receptors have been identified…