Introduction:
Vascular diseases are among the most widespread diseases in the wrold. Among them, the chronic venous insufficiency (CVI) of the lower limbs represents one of the diseases with higher incidence and prevalence in the female gender. CVI is a disease characterized by a progressive deterioration in the vascular funcitonality, expecially of the lower limbs, which in the long term determines the onset of pain, aedema, inflammation. Omikron Titalia, S.R.I, US 2025/0295690)
CVI is an “outflow disease”, consequent to structural aminomalies involving the walls of veins, of dilative type (varices) or obstructive type, the latter including, among the varous symptoms, deep vein thromboses (DVT), sueprficial vein thromboses (SVT) and post-thrombotic syndromes. (Omikron Titalia, S.R.I, US 2025/0295690)
CVI clinical pictures are very variegated and the intesity and gravity of the disease can be extremely variable, by determining the onset of alterations at aethetical level only (such as reitcular varices, telangiectasia), until considerable conditions of tissue damage (such as lipodermatosclerosis, trophic ulcers). Omikron Titalia, S.R.I, US 2025/0295690)
Treatments:
Once a correct anamnestic collection and specific diagnsotics, including instrumental analysis (for example, hemodynamic cartography with eco-colour doppler) have been performed, the currently available main strategies for therapeutically treating CVI provide to adopt adquate stands of conduct aimed at guarnateeing a better lifesyle to the patient. The use of a graduated and decreasig elastic compression, especially to face the moments of obliged sedentary lifestyle together with supporting medical therapy with the prupose of obtianing a clinical and hemodynamic stabilization of the disease. Omikron Titalia, S.R.I, US 2025/0295690)
Sulodexide + Favlones: Omikron Titalia, S.R.I, US 2025/0295690) discloses a composition for oral use for the treatment of vascular diseases which cinludes sulodexide and one or more flavonoids selected among diosmin, hesperidin, troxerutin, oxerutin, quercitin and hesperidin. Sulodexide is a biological drug of natural original purfied by porcine iterstinal mucosa, consisting of glycosaminoglycans (GAGs) consisting by 80% of heparin with low MW and the remaining 20% of dermatan sulfate (DS). It is characterized by a complex pharmacological profile with several effects on the vascular system: antithrombotic, profibrinolytic, direct ani-inflammatory on the MMP-2 and MMP-9, structural for reintegration of glycocayx and prtoective for endothelium. Favonoids represtn a lass of chompounds of natural original which include a skelton C15 consisting of two aromatic rings and one heterocyclic ring. The Diosmin, hesperidin and/or troxerutin usable can by of synthetic or natural origin such as foundplant extracts. .