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Two general mechanisms have been proposed by which DCs might maintain peripheral tolerance. The first is that a subtype of specialized regulatory DCs is involved. The second is that all…

Th1 and Th2 patters of cytokine secretion correspond to activated effector phenotypes generated during an immune response. They do not exist among naive T cells. When first stimulated by antigen…

There are two main DC subsets; (1) Myeloid (mDC) and (2)  Myeloid DC and pDC different in Toll-like receptors able to sense activation signals from pathogens. Several other functional discrepancies have…

DCs have been identified as the most effective antigen presenting cells (APC). They have long dendritic processes and possess an exceptional capability to capture antigens (Ags), process and present antigenic…

n vitro, maturation/activation can be induced by a number of stimuli, including cytokines such as TNF-? and/or other cytokines, monocyte-conditioned medium, or CD40 receptor cross-linking. Immature DC comparable to those…

Drugs which Inhibit DC Maturation and/or Function A diverse variety of pharmacologic agents have been shown to inhibit DC maturation and to promote their tolerogenicity. Acetylsalicylic acid (Aspirin;) Although asprin has…

As many as six subsets of DCs have been described in mice including mDCs and pDCs which are also found in Both DC types are professional antigen presenting cells (APCs) but…

Human DCs comprise at least four types defined under cytokine-driven conditions in vitro. These include conventional or "myeloid" DCs: (1) CD14+ blood monocyte-derived DCs (moDCs); 2) dermal DCs or interstitial…

Cytokines produced by DCs DCs are known to produce the following cytokines: DCs are efficient producers of IL12 that acts in inducing Th1 responses upon antigen presentation by these APC. …

The dendritic cell is one of the major means by which innate and adaptive immune systems communicate. It is believed that these cells shape the adpative immune response by the…