inhibition of DC maturation

Drugs which Inhibit DC Maturation and/or Function A diverse variety of pharmacologic agents have been shown to inhibit DC maturation and to promote their tolerogenicity. Acetylsalicylic acid (Aspirin;) Although asprin has…

DC subsets in mice

As many as six subsets of DCs have been described in mice including mDCs and pDCs which are also found in Both DC types are professional antigen presenting cells (APCs) but…

DC subsets in humans

Introduction: Human DCs comprise at least four types defined under cytokine-driven conditions in vitro. These include conventional or "myeloid" DCs: (1) CD14+ blood monocyte-derived DCs (moDCs); 2) dermal DCs or…

cytokines & chemokines produced

Cytokines produced by DCs DCs are known to produce the following cytokines: DCs are efficient producers of IL12 that acts in inducing Th1 responses upon antigen presentation by these APC. …

dendritic cells

Videos:  Genentech (showing phagocytic cells taking in antigens) Introduction: The dendritic cell is one of the major means by which innate and adaptive immune systems communicate. It is believed that…

monocytes

See also Macrophages and T cell priming by DCs Introduction: Cells of the monocytic lineage play an essential role in initiating and maintaining immune responses by acting as antigen-presenting cells.…

white blood cells/leukocytes

Classes of Leukocytes White blood cells or "leukocytes" combat infection and in some cases phagocytose and digest debris. White blood cells are traditionally grouped into three major categories based on…

Immune cells

Monocytes Monocytes, unlike granulocytes, are long lived and can differentiate to become tissue resident macrophages and dendritic cells. Cells of the monocytic lineage play an essential role in initiating and…

B cell receptor (BCR) signalling

See also T cell activaiton in immune cells Antigen recognition by B cells is mediated by the B cell receptor (BCR), a surface-bound immunoglobulin in complex with signaling componets CD79alpha…

Antigen fusions

Particular Type of Antigen-Fusion Polypeptides Thermally Responsive Polymers Fused to Antigens --Antigen-Carrier-Elastin-Like Peptide Fusion Peptides: Krebs (US13/990344) discloses fusion proteins of an immunogenic carrier protein containg a thermally-responsive aggregation (TRA) polypeptide…