drug manufacture
See also Animals Models in Biotechnology FDA approved drugs (search by drug name, active ingredient or application #) Companies which assist in clinical trial development: Amarex Center for Biologics Evaluation and…
Moving Bed
Simulated Moving Bed (SMB) chromatography: Introduction: A specific way of operating continous chromatography is called simulated moving bed (SMB) chromatography. In SMB all the chromatography columns are periodically and…
Depression
Introduction: Depression is neurological disorder with psychiatric symptoms. While it is often categorized as a mental health condition, research has shown that depression is linked to structural and functional changes…
Anziety
Selective Serotonin Reuptake Inhibitors: Lexapro (escitalopram): Lexapro (escitalopram) is an antidepressant from the group of drugs called selective serotonin reuptake inhibitors (SSRIs) and is used to treat certain types of…
Oxidized and Reduced Variants
See also Oxidation and Reduction in Biochemistry Disulfide Bond Variants Disulfide reduced variants have one more disulfide bonding cystein(s) chemically reduced to the free thiol form. This variant can be monitored…
Anion Mixed Mode (cation exchanger)
Anion exchange and hydrophilic interaction: Negatively charged mixed mode ligands below to the cation exchanger mixed mode (for example CaptoAdhere) (Melinda, US 20170058019) Examples include Capto-QTM which is a strong anion exchange and…
microparticles
Companies: Elektrofi (developed Hpercon which are protein microparticles. Gentle dehydration results in smooth, spherical microparticles that dissolve into fully functional protein monomers in the subcutaenous space. They take drug substances…
Brain Drug Delivery
Diseases of the CNS remain the world's leading cause of disabilities, accounting for more hospitalization and prolonged care than almost all other diseases combined. Such CNS diseases include brain tumors,…
Altered Effector Function
The effector functions mediated by the antibody Fc region can be divided into (1) effector functions that operate after binding of antiobdy to an antigen (these funcitons involved the participation…
BispAb Formats
A main discrimination of recombinant bispecific antibodies is format and in particular the presence or absecne of an Fc region. Bispecific antibodies (biSpAbs) with no Fc will lack Fc mediated…