Role of complement system in Disease

November 9, 2022Posted inPatent Law Cases
See also therapeutic antibodies against specific complement components in the "antibodies" section.  See also CR2 targetting of complement inhibitors for treatment of disease under "pharmacology"   See also specific diseases throughout ypatent for the role which complement plays in these…

Complement receptors

November 8, 2022Posted inimmunology
See also Regulation of the Complement system . See also the use of complement receptors for drug targeting (under "pharmacology" and "drug delivery"). There are three known gene superfamilies of complemen…

Functions of the complement system

November 8, 2022Posted inimmunology
Complement has a variety of important functions which includes: (1) opsonization of antigens: including bacteria by phagocytosis. The complement component, C3b is the major opsonin of the complement system. Phagocytic cells, as…

Functions of the complement system

November 8, 2022Posted inimmunology
Complement has a variety of important functions which includes: (1) opsonization of antigens: including bacteria by phagocytosis. The complement component, C3b is the major opsonin of the complement system. Phagocytic cells, as…

Complement System

November 8, 2022Posted inPatent Law Cases
The complement system consists of about 31 proteins, acting within a cascade-like reaction sequence, serving as control proteins or as cellular receptors. Some of the proteins are enzymes (C1r, C1s,…

CRISP Gene Editing

July 4, 2022Posted inPatent Law Cases
Companies: Editas  Excision Bio Therapeutics Prime Medicine. Pairwise.  Tome Biosciences. EditCo See also chimeric antigen receptors (CARs) under Cancer treatment Programmable nucleases such as CRISPR-Cas9 make double strand DNA breaks (DSBs) that…

Graft-versus-host-disease (GVHD)

June 9, 2022Posted inimmunology
Graft-versus-host-disease (GVHD): GVHD (graft-versus-host-disease) occurs when donor derived T cells recognize and react to histo-incompatible recipient antigens leading to a variety of host tissue injuries. GVHD is the major cause of morbidity…

Extra Light Chains

June 7, 2022Posted inPatent Law Cases
A species identified as a mAb monomer with an additional light chain covalently associated through a disulfide bond formed between a L chain cystein and an engineered cystein in either…

Liver transplantation

May 2, 2022Posted inimmunology
Partial Liver Transplantation Massive hepatic resection is the only option for some patients with primary or secondary liver tumors. With regard to small-for-size (SFS) liver transplantation, the use of partial…

Transplantation

May 2, 2022Posted inimmunology
United Network for Organ Sharing See also Kidney Diseases  See also MHC In 1901, Landseiner discovered ABO blood group antigens. In 1954, Murray performed the first successful kidney transplant between…