BispAb Formats
A main discrimination of recombinant bispecific antibodies is format and in particular the presence or absecne of an Fc region. Bispecific antibodies (biSpAbs) with no Fc will lack Fc mediated…
Conjugation & Linkers
Antibody-Drug Conjugates (ADCs) are designed to bind to cell surface receptors and get internalized thorugh receptor medaited endocytosis, then trafficked into endosomes and ultimately lysosomes. Following internalization, ADC antigen complexes…
Ultrasmall Superparamagnetic Iron Oxide Nanoparticles
SPIO refers to superparamagentic iron oxide particles. They are commonly made of maghemite (Fe2O3) or magnetite (Fe3O4) having crystal-containing regions of unpaired spins. Those magnetic domains are disordered in the…
RNA Interference
Companies: n-Lorem (charitable antisense therapy for rare diseases). Avidity Biosciences (acquired by Novartis) (Antibody Oligonucleotide Conjugates (AOC™) platform) Introduction: RNA interference (RNAi) is an endogenous cellular process in which double-stranded…
Engineering of BiAbs to Facilitate Production/Purification
See also purification of bi-specific antibodies under particular antibodies purified In general, IgG type bispecific antibodies are composed of two types of H chains (an H chain for antigen A…
Thrombotic microangiopathies (TMA)
The term thromobitic microangiopathy (TMA) encompasses a group of conditions that are defined by, or result from, a similar histopathological lesion. Hemolytic uremic syndrome HUS), thrombotic thrombocytopenic purpura (TTP) and…
Applications of Complement Regulators
See also specific diseases for references to CRegs and Drug Targetting under Pharmacology CRegs for the Treatment of Diseases CR1: Levin (US 6,169,068) teaches a method for treating diseases involving complment by…
Regulation of the complement system
See also Applications of Cregs: Complement Receptor 1 (CR1; CD35; C3b/C4b receptor): is present on erythrocytes, monocytes/macrophages, granulocytes, B cells, some T cells, splenic follicular dendritic cells and glomerular pdocytes. CR1…
Regulation of the complement system
See also complement inhibitor targetting under "Pharmacology" and "Drug delivery" See also Human Complement Regulatory Proteins (CRegs) See also disease mechanisms of viruses and bacteria for how pathogens use complement regulatory proteins to evade the…
Complement Assays
Various assays/methods can be used to mesasure activities of complement pathway molecules and activaiton of the complement system. (see US Patent No. 6,087,120 and Newell, J Lab Cin Med, 100:437-44,…