Oxidized and Reduced Variants

See also Oxidation and Reduction in Biochemistry Disulfide Bond Variants  Disulfide reduced variants have one more disulfide bonding cystein(s) chemically reduced to the free thiol form. This variant can be monitored…

Anion Mixed Mode (cation exchanger)

Anion exchange and hydrophilic interaction:  Negatively charged mixed mode ligands below to the cation exchanger mixed mode (for example CaptoAdhere) (Melinda, US 20170058019) Examples include Capto-QTM which is a strong anion exchange and…

microparticles

Companies:  Elektrofi (developed Hpercon which are protein microparticles. Gentle dehydration results in smooth, spherical microparticles that dissolve into fully functional protein monomers in the subcutaenous space. They take drug substances…

Brain Drug Delivery

Diseases of the CNS remain the world's leading cause of disabilities, accounting for more hospitalization and prolonged care than almost all other diseases combined. Such CNS diseases include brain tumors,…

Altered Effector Function

The effector functions mediated by the antibody Fc region can be divided into (1) effector functions that operate after binding of antiobdy to an antigen (these funcitons involved the participation…

BispAb Formats

A main discrimination of recombinant bispecific antibodies is format and in particular the presence or absecne of an Fc region. Bispecific antibodies (biSpAbs) with no Fc will lack Fc mediated…

Conjugation & Linkers

Antibody-Drug Conjugates (ADCs) are designed to bind to cell surface receptors and get internalized thorugh receptor medaited endocytosis, then trafficked into endosomes and ultimately lysosomes. Following internalization, ADC antigen complexes…

RNA Interference

Companies: n-Lorem (charitable antisense therapy for rare diseases). Avidity Biosciences (acquired by Novartis) (Antibody Oligonucleotide Conjugates (AOC™) platform) Gatehouse Bio (uses AI to decode its landscape of RNAis) Introduction: RNA…