GATA-3/Tbet
The present of GATA-3 mRNA in naive T cells and induction of T-bet mRNA after cell activation, even in the absence of Stat1-mediated signals, are consistent with the early transcription…
TGF-beta
TGF-beta superfamily is a large family of multifunctional proteins that regulate a variety of cellular functions including cellular proliferation, migration, differentiation and apoptosis. Members of the transforming growth factor beta…
STATS
Introduction to Signal Transducer and Activator of Transcription (STATs): STATs are latent transcription factors residing in the cytoplasm that become activated by phosphorylation on a single tyrosine residue. This phosphorylation…
THC
Introduction: Both delta-8 and delta-9 cannabinoids have a chain of carbon atoms, but delta-8 has the double bond on the eighth carbon, whereas delta-9 has it on the ninth carbon. This…
Cannabinoid receptors
Companies working on Cannabinoids for treatment of Disease: GW Pharmaceuticals Gold Seal (San Francisco based cannabis brand that specializes in high end flower). Introduction: Two cannabinoid receptors have been identified…
G Protein coupled Receptors
See also G proteins Introduction: G protein-coupled receptors(GPCRs) comprise a large superfamily of receptors which are prevalent through-out the human body, comprising about 60% of known cellular receptor types. GPCRs…
Enzyme Linked Receptors
See also Signal Transduction Enzyme linked receptors, when activated, either function directly as enzymes or are directly associated with enzymes that they activate. They are formed by single pass transmembrane…
Receptor tyrosine kinases
Videos: HER pathway and cancer VEGF and EGFR pathways Introduction: Receptor tyrosine kinases (RTKs) influence the cell cycle, cell mitration, cell metabolism and cell proliferation --virtually all aspects of the…
Receptor regulation
(1) Sensitization/Up Regulation: is a process whereby a cell becomes more responsive to a given concentration of a compound. This can occur in the following ways:Increase in functionality: deals with increased…
FcRn
See also use of FcRn for antibody purification See also engineering antibodies to increase/decrease binding affinity for FcRn The MHC class I-related neonatal Fc receptor (FcRn) is also known as the Brambell…