Types of nanoparticles
Gene delivery is, arguably, the biggest bottleneck in gene therapy. Adeno-associated virus (AAVs) are the historical mainstay, but they are expensive to manufacture and have payload limits and immunological issues.…
Magnetic nanoparticles
See also antibodies as drug targetting agents Introduction: Magnetic nanoscale particles are of particular interest with respect to nanoparticles due to their magnetic properties. These nanoparticles ave been used to…
Nanoparticles
Companies: Bind therapeutics (developing "accurins" which polymeric nanoparticles which target and accumulate at disease sites). Continuity Biosciences. (The Continuity Biosciences technology portfolio ranges from nanofluidic systems for drug delivery to cell storage…
Immunoadhesins
immunoadhesin combines the framework sequences from a human mAb with sequences from a human protein that carries a target-recognition function. The most common example of this type of fusion protein combines the…
Vector design
Head-to-head promoter expression vector: refers to a promoter pair being placed in close proxmity so that transcription of two gene framgents driven by the promoters occurs in opposite directions. (WO2004/061104) provides…
Gene delivery
FDA cellular & gene therapy guidance Introduction: Gene therapy involves the transfer and expression of a therapeutic gene. The nucleic acid transfer needs to have a dominant effect on the cell's…
Gelatin
Gelatin: is a collection of high molecular weight peptides produced by hydrolysis of collagen usually isolted from bovine or porcine skin. Gelatin is obtained by the partial hydrolysis of collagen dervied…
Reversible gels
"Smart" polymers, which reversibly change their physical properties in response to small and controllable stimuli (e.g., changes in pH, termpature, and light), reversibly cycle between an extended and hydrophilic random…
Hydrogels
Introduction: Hydrogels have been used extensively in the development of smart drug delivery systems. A hydrogel is a network of hydrophilic polymers that can swell in water and hold a…
Cleavable Linkers/sites
See also detection of activatable antibodies under Diagnostics. See also Conjugation and Linkers See also Particular Contaminants under Antibody Purification Cleavable Linkers: Problem of stability with cleavable linekrs: A peptidic linker…