Cleavable Linkers/sites

See also detection of activatable antibodies under Diagnostics. See also Conjugation and Linkers See also Particular Contaminants under Antibody Purification Cleavable Linkers: Problem of stability with cleavable linekrs: A peptidic linker…

Complement receptor drug targetting

See also Complement Receptors under Immunology CR2 Fusion Constructs CR2-FH fusion proteins:  Gilkeson (US 7759304; US2008/0221011A1) and WO2007/149567A2) discloses a CR2-FH fusion construct which can be used to treat diseases in…

Antibodies as drug carriers

Targeted therapy using monoclonal antibodies (mAbs) has reolutionized cancer treamtent, with several mAbs recognizing antigens expressed on the surfaces of tumor cells already haivng demonstrated their clinical potential. As antibodies…

Drug Delivery

Introduction: Allogeneic ex vivo therapies are in development where healthy donor cells ahve been modified to overcome allo-rejection with the purpose of creating so-called "off-the-shelf" cell therapies. Similarly, induced pluripotent…

Cluster of differentiation (CD)

CD molecule information (NIH) Common cell surface markers are the following: CD3 which is a T cell receptor coreceptor.  CD4 molecule is a relatively non-polymorphic, 55 kDa surface glycoprotein comprised of four…

Surface markers

Activation Markers CD62L, CCR7, CD45RA and CD28 are present on naive cells. Cells which no longer express these cell surface markers have been previously activated. CD45RO, granzyme A and bcl2…

Prokaryotes

Introduction: The term prokaryote describes a cell type or collectively the organisms in the Domains Bacteria and Archaea. The two prokaryotic domains, Arcahe and Bacteria, are not closely related, although…

Organs & Tissues

Internal organs characteristic of vertebrates includes a liver, kidneys, and endocrine glands. All vertegrates have a heart and a closed circulatory system. Endocrine glands: secrte hormones that help regulate many…

Nuclear receptors

See also receptors The nuclear receptor superfamily is a large superfamily whose ligands are small hydrophobic signal molecules which diffuse directly across the plasma membrane and bind to these intracellular…