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Head-to-head promoter expression vector: refers to a promoter pair being placed in close proxmity so that transcription of two gene framgents driven by the promoters occurs in opposite directions. (WO2004/061104) provides…

FDA cellular & gene therapy guidance Introduction: Gene therapy involves the transfer and expression of a therapeutic gene. The nucleic acid transfer needs to have a dominant effect on the cell's…

Gelatin: is a collection of high molecular weight peptides produced by hydrolysis of collagen usually isolted from bovine or porcine skin. Gelatin is obtained by the partial hydrolysis of collagen dervied…

"Smart" polymers, which reversibly change their physical properties in response to small and controllable stimuli (e.g., changes in pH, termpature, and light), reversibly cycle between an extended and hydrophilic random…

Introduction: Hydrogels have been used extensively in the development of smart drug delivery systems. A hydrogel is a network of hydrophilic polymers that can swell in water and hold a…

See also detection of activatable antibodies under Diagnostics. See also Conjugation and Linkers See also Particular Contaminants under Antibody Purification Cleavable Linkers: Problem of stability with cleavable linekrs: A peptidic linker…

See also Complement Receptors under Immunology CR2 Fusion Constructs CR2-FH fusion proteins:  Gilkeson (US 7759304; US2008/0221011A1) and WO2007/149567A2) discloses a CR2-FH fusion construct which can be used to treat diseases in…

Companies: Ridge Bio (ML-driven enzyme and linker engineering platforms) Targeted therapy using monoclonal antibodies (mAbs) has reolutionized cancer treamtent, with several mAbs recognizing antigens expressed on the surfaces of tumor…

Introduction: Allogeneic ex vivo therapies are in development where healthy donor cells ahve been modified to overcome allo-rejection with the purpose of creating so-called "off-the-shelf" cell therapies. Similarly, induced pluripotent…