Antibodies as drug carriers

Companies: Ridge Bio (ML-driven enzyme and linker engineering platforms) Targeted therapy using monoclonal antibodies (mAbs) has reolutionized cancer treamtent, with several mAbs recognizing antigens expressed on the surfaces of tumor…

Drug Delivery

Introduction: Allogeneic ex vivo therapies are in development where healthy donor cells ahve been modified to overcome allo-rejection with the purpose of creating so-called "off-the-shelf" cell therapies. Similarly, induced pluripotent…

Cluster of differentiation (CD)

CD molecule information (NIH) For a nice listing of CD markers as antigen in various cell types see Lee "Spatial tissue analysis of secondary sarcoma following CAR T cell therapy…

Surface markers

Activation Markers CD62L, CCR7, CD45RA and CD28 are present on naive cells. Cells which no longer express these cell surface markers have been previously activated. CD45RO, granzyme A and bcl2…

Prokaryotes

Introduction: The term prokaryote describes a cell type or collectively the organisms in the Domains Bacteria and Archaea. The two prokaryotic domains, Arcahe and Bacteria, are not closely related, although…

Organs & Tissues

Introduction/Definitions: Internal organs characteristic of vertebrates includes a liver, kidneys, and endocrine glands. All vertebrates have a heart and a closed circulatory system. Endocrine glands: Endocrine glands secrete hormones that…

Nuclear receptors

See also receptors The nuclear receptor superfamily is a large superfamily whose ligands are small hydrophobic signal molecules which diffuse directly across the plasma membrane and bind to these intracellular…

Hemorheology

Hemorheology  is the science of blood circulatory flow mechanics. It is important with respect to abnormal blood physiologic function, disease, premature fatigue or reduced performance following exposure to non-disease related…

Lipid Droplets

Structure of Lipid Droplets: Lipid droplets are organelles with a different structure form the rest of the endomembrane system. They consist of a netral lipid core surrounded by a single…