Fc receptor modification
Increasing Serum Half-life See engineering antibodies for pH dependent affinity Introduction The Fc region of an antibody interacts with a number of Fc receptors and ligands, imparting an array of important…
pH dependent antibodies
See also Fc Receptors See also FcRn recpetor See also Fc modifications Increasing the half lives of therapeutics can decrease the frequency of patient inections and allow the administration of low concentrations of…
modified for binding affinity
Introduction The targets of monoclonal antibodies can be classified into two groups: membrane-bound antigens and soluble antigens. Targets of food and drug adminsitration (FDA) approved mAbs for membrane boudn antigends…
humanized antibodies
Useful Links: IMGT (International ImMunoGeneTics Information system; useful information on germline gene repertoire) Because mice are convenient for immunization and recognize most human anitgens as foreign, mAbs against human targets…
polyclonal antibodies
"Polyclonal antibody" refers to an immunoglobulin produced form more than a single clone of plasma cells (e.g., B lymphocytes). Although each B-cellclone produces an antibody which is specific for one particular…
monoclonal antibodies
Immunisation of an animal with an antigen results in the production of polyclonal antibodies in other words, different antibodies with different specificities and affinities. A monoclonal antibody refers to an…
bi-specific antibodies
As to production of bi-specific antibodies see outline. Specific Types of BsAbs see outline Introduction: Most natural antibodies are bi or multivalent molecules comprising identical antigen binding sites. The exception are…
antibody fragments
Antibody fragments comprise a portion of a full-lenght antibody, as for example, the antigen binding or variable region of a full length antibody. Antibody fragments that contain the idiotype (antigen-binding fragment)of the…
catalytic antibodies
see also Proteoytic antibodies and IVIG preparations under "protein purification" The terms "abzyme" or "catalytic immunoglobulin" are used to describe antibodies possessing enzymatic activity. Examples of catalytic reactions that may be catalyzed by the…
isotypes
See also "Fc receptors" under "signal transduction" See also antibody glycosylation under glycosylation. See also IgA Introduction: The term "isotype" refers to the classificaiton of an antibody's heavy or light chain constant region. For example,…