Complement System
The complement system consists of about 31 proteins, acting within a cascade-like reaction sequence, serving as control proteins or as cellular receptors. Some of the proteins are enzymes (C1r, C1s,…
CRISP Gene Editing
Companies: Editas Excision Bio Therapeutics Prime Medicine. Pairwise. Tome Biosciences. EditCo. Sigma/Millipore (good selection products) Life Edit. Tessera Beam Therapeutics Mamouth Biosciences. Data bases: University Paris-Saclay (CRISP db) See also chimeric antigen…
Graft-versus-host-disease (GVHD)
Introduction/Definitions: Autograph: transplanted tissue from one site on a donor and the recipient. Typical examples are skin replacement in burn repair and the use of a vein to fashion a…
Extra Light Chains
A species identified as a mAb monomer with an additional light chain covalently associated through a disulfide bond formed between a L chain cystein and an engineered cystein in either…
Liver transplantation
Partial Liver Transplantation Massive hepatic resection is the only option for some patients with primary or secondary liver tumors. With regard to small-for-size (SFS) liver transplantation, the use of partial…
Transplantation
United Network for Organ Sharing Companies: eGeneis (developing porcine organs for transplant) See also Kidney Diseases See also MHC In 1901, Landseiner discovered ABO blood group antigens. In 1954, Murray…
Light scattering
Companies: ALV. Brookhaven Instruments Malvern. Wyatt Light scattering is one of the few absolute methods available for the determination of molecular mass and structure and is applicable over a broader…
Mas spectrometry
Mass spectrometry (MS) has gained importance in the anlytics of biopharmaceuticals, taking different complementary approaches ranging from peptide-based sequencing to direct analysis fo intact proteins and protein assmeblies. (Rosati, Nature…
Chimeric antigen receptors (CARS)
Websites: ClinicalTrials.gov (lists many active CART trials). See also Enzymes and CRISP Introduction to CARs/CARTs and TCRs Chimeric antigen receptors (CARs) are engineered receptor proteins, while chimeric antigen receptor T…
Tumor immunology
Tumour Immunology Strategies cancer vaccines refers to therapeutic immunization in patients with cancer, with the main aim of breaking tolerance toward self-tumor-associated antigens. One strategy is to pulse antigen presenting cells…