Complement Pathways
There are 3 distinct pathways of complement activation. The classical system is antibody dependent whereas the other 2 pathways, lectin and alternative, are antibody independent and are initiated by reaction…
Role of complement system in Disease
See also therapeutic antibodies against specific complement components in the "antibodies" section. See also CR2 targetting of complement inhibitors for treatment of disease under "pharmacology" See also specific diseases throughout ypatent for the role which complement plays in these…
Complement receptors
See also Regulation of the Complement system . See also the use of complement receptors for drug targeting (under "pharmacology" and "drug delivery"). There are three known gene superfamilies of complemen…
Functions of the complement system
Complement has a variety of important functions which includes: (1) opsonization of antigens: including bacteria by phagocytosis. The complement component, C3b is the major opsonin of the complement system. Phagocytic cells, as…
Functions of the complement system
Complement has a variety of important functions which includes: (1) opsonization of antigens: including bacteria by phagocytosis. The complement component, C3b is the major opsonin of the complement system. Phagocytic cells, as…
Complement System
The complement system consists of about 31 proteins, acting within a cascade-like reaction sequence, serving as control proteins or as cellular receptors. Some of the proteins are enzymes (C1r, C1s,…
CRISP Gene Editing
Companies: Editas Excision Bio Therapeutics Prime Medicine. Pairwise. Tome Biosciences. EditCo. Sigma/Millipore (good selection products) Life Edit. Tessera Beam Therapeutics Mamouth Biosciences. Data bases: University Paris-Saclay (CRISP db) See also chimeric antigen…
Graft-versus-host-disease (GVHD)
Introduction/Definitions: Autograph: transplanted tissue from one site on a donor and the recipient. Typical examples are skin replacement in burn repair and the use of a vein to fashion a…
Extra Light Chains
A species identified as a mAb monomer with an additional light chain covalently associated through a disulfide bond formed between a L chain cystein and an engineered cystein in either…
Liver transplantation
Partial Liver Transplantation Massive hepatic resection is the only option for some patients with primary or secondary liver tumors. With regard to small-for-size (SFS) liver transplantation, the use of partial…